Overview
| Uniprot ID | P62278 |
|---|
| Protein Name | Small ribosomal subunit protein uS15 |
|---|
| Gene Name | Rps13 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 34 |
KLTSDDVKEQIYKLA |
| 43 |
QIYKLAKKGLTPSQI |
| 70 |
VRFVTGNKILRILKS |
| 78 |
ILRILKSKGLAPDLP |
| 9 |
GRMHAPGKGLSQSAL |
| 93 |
EDLYHLIKKAVAVRK |
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Protein Sequence
10
MGRMHAPGKG
20
LSQSALPYRR
30
SVPTWLKLTS
40
DDVKEQIYKL
50
AKKGLTPSQI
60
GVILRDSHGV
70
AQVRFVTGNK
80
ILRILKSKGL
90
APDLPEDLYH
100
LIKKAVAVRK
110
HLERNRKDKD
120
AKFRLILIES
130
RIHRLARYYK
140
TKRVLPPNWK
150
YESSTASALV
A
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0022626 |
cytosolic ribosome |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0005840 |
ribosome |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:1990932 |
5.8S rRNA binding |
| Molecular Function |
GO:0048027 |
mRNA 5'-UTR binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:0070181 |
small ribosomal subunit rRNA binding |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Biological Process |
GO:0033119 |
negative regulation of RNA splicing |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0140242 |
translation at postsynapse |
| Biological Process |
GO:0140236 |
translation at presynapse |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.