Overview
| Uniprot ID | P62314 |
|---|
| Protein Name | Small nuclear ribonucleoprotein Sm D1 |
|---|
| Gene Name | SNRPD1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 86 |
LLVDVEPKVKSKKRE |
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303)
Protein Sequence
10
MKLVRFLMKL
20
SHETVTIELK
30
NGTQVHGTIT
40
GVDVSMNTHL
50
KAVKMTLKNR
60
EPVQLETLSI
70
RGNNIRYFIL
80
PDSLPLDTLL
90
VDVEPKVKSK
100
KREAVAGRGR
110
GRGRGRGRGR
GRGRGGPRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0000243 |
commitment complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0034709 |
methylosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0034715 |
pICln-Sm protein complex |
| Cellular Component |
GO:0071011 |
precatalytic spliceosome |
| Cellular Component |
GO:0030532 |
small nuclear ribonucleoprotein complex |
| Cellular Component |
GO:0034719 |
SMN-Sm protein complex |
| Cellular Component |
GO:0097526 |
spliceosomal tri-snRNP complex |
| Cellular Component |
GO:0005685 |
U1 snRNP |
| Cellular Component |
GO:0005689 |
U12-type spliceosomal complex |
| Cellular Component |
GO:0005686 |
U2 snRNP |
| Cellular Component |
GO:0071007 |
U2-type catalytic step 2 spliceosome |
| Cellular Component |
GO:0071005 |
U2-type precatalytic spliceosome |
| Cellular Component |
GO:0005684 |
U2-type spliceosomal complex |
| Cellular Component |
GO:0005687 |
U4 snRNP |
| Cellular Component |
GO:0046540 |
U4/U6 x U5 tri-snRNP complex |
| Cellular Component |
GO:0005682 |
U5 snRNP |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:1990446 |
U1 snRNP binding |
| Biological Process |
GO:0036261 |
7-methylguanosine cap hypermethylation |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0008380 |
RNA splicing |
| Biological Process |
GO:0000245 |
spliceosomal complex assembly |
| Biological Process |
GO:0000387 |
spliceosomal snRNP assembly |
| Biological Process |
GO:0000244 |
spliceosomal tri-snRNP complex assembly |
| Biological Process |
GO:0000388 |
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) |
| Biological Process |
GO:1903241 |
U2-type prespliceosome assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.