Overview
| Uniprot ID | P62318 |
|---|
| Protein Name | Small nuclear ribonucleoprotein Sm D3 |
|---|
| Gene Name | SNRPD3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 84 |
LKNAPMLKSMKNKNQ |
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity)
Protein Sequence
10
MSIGVPIKVL
20
HEAEGHIVTC
30
ETNTGEVYRG
40
KLIEAEDNMN
50
CQMSNITVTY
60
RDGRVAQLEQ
70
VYIRGSKIRF
80
LILPDMLKNA
90
PMLKSMKNKN
100
QGSGAGRGKA
110
AILKAQVAAR
120
GRGRGMGRGN
IFQKRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071013 |
catalytic step 2 spliceosome |
| Cellular Component |
GO:0000243 |
commitment complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0034709 |
methylosome |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0034715 |
pICln-Sm protein complex |
| Cellular Component |
GO:0071011 |
precatalytic spliceosome |
| Cellular Component |
GO:0030532 |
small nuclear ribonucleoprotein complex |
| Cellular Component |
GO:0034719 |
SMN-Sm protein complex |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Cellular Component |
GO:0097526 |
spliceosomal tri-snRNP complex |
| Cellular Component |
GO:0005697 |
telomerase holoenzyme complex |
| Cellular Component |
GO:0005685 |
U1 snRNP |
| Cellular Component |
GO:0005689 |
U12-type spliceosomal complex |
| Cellular Component |
GO:0005686 |
U2 snRNP |
| Cellular Component |
GO:0071007 |
U2-type catalytic step 2 spliceosome |
| Cellular Component |
GO:0071005 |
U2-type precatalytic spliceosome |
| Cellular Component |
GO:0005684 |
U2-type spliceosomal complex |
| Cellular Component |
GO:0005687 |
U4 snRNP |
| Cellular Component |
GO:0046540 |
U4/U6 x U5 tri-snRNP complex |
| Cellular Component |
GO:0005682 |
U5 snRNP |
| Cellular Component |
GO:0005683 |
U7 snRNP |
| Molecular Function |
GO:0019899 |
enzyme binding |
| Molecular Function |
GO:0071208 |
histone pre-mRNA DCP binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0070034 |
telomerase RNA binding |
| Molecular Function |
GO:0071209 |
U7 snRNA binding |
| Biological Process |
GO:0036261 |
7-methylguanosine cap hypermethylation |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0071045 |
nuclear histone mRNA catabolic process |
| Biological Process |
GO:0006479 |
protein methylation |
| Biological Process |
GO:0008380 |
RNA splicing |
| Biological Process |
GO:0000245 |
spliceosomal complex assembly |
| Biological Process |
GO:0000387 |
spliceosomal snRNP assembly |
| Biological Process |
GO:0000244 |
spliceosomal tri-snRNP complex assembly |
| Biological Process |
GO:0000388 |
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) |
| Biological Process |
GO:1903241 |
U2-type prespliceosome assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.