Search Results
Overview
| Uniprot ID | P62329 |
|---|---|
| Protein Name | Thymosin beta-4 |
| Gene Name | Tmsb4x |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | PDMAEIEKFDKSKLK |
| 26 | KKTETQEKNPLPSKE |
| 32 | EKNPLPSKETIEQEK |
Function
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0003788 | actin monomer sequestering activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:1902037 | negative regulation of hematopoietic stem cell differentiation |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:2001171 | positive regulation of ATP biosynthetic process |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.