Search Results
Overview
| Uniprot ID | P62330 |
|---|---|
| Protein Name | ADP-ribosylation factor 6 |
| Gene Name | ARF6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | WDVGGQDKIRPLWRH |
| 7 | *MGKVLSKIFGNKEM |
Function
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:16737952, PubMed:18400762, PubMed:21170023, PubMed:32103017, PubMed:7589240). GTP-bound form plays an important role in the transport of multiple palmitoylated proteins form the Golgi to the plasma membrane (PubMed:37461827). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Potentiates the neurite outgrowth in primary neurons by interacting with the molecular adapter APBB1 (PubMed:36250347). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization (PubMed:36017701). Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0090543 | Flemming body |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0031996 | thioesterase binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0099562 | maintenance of postsynaptic density structure |
| Biological Process | GO:2000171 | negative regulation of dendrite development |
| Biological Process | GO:2000009 | negative regulation of protein localization to cell surface |
| Biological Process | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0120183 | positive regulation of focal adhesion disassembly |
| Biological Process | GO:0051549 | positive regulation of keratinocyte migration |
| Biological Process | GO:1903438 | positive regulation of mitotic cytokinetic process |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0050714 | positive regulation of protein secretion |
| Biological Process | GO:0034394 | protein localization to cell surface |
| Biological Process | GO:1905345 | protein localization to cleavage furrow |
| Biological Process | GO:0036010 | protein localization to endosome |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0060998 | regulation of dendritic spine development |
| Biological Process | GO:0051489 | regulation of filopodium assembly |
| Biological Process | GO:1905606 | regulation of presynapse assembly |
| Biological Process | GO:0035020 | regulation of Rac protein signal transduction |
| Biological Process | GO:0097178 | ruffle assembly |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.