Search Results

Overview

Uniprot ID	P62333
Protein Name	26S proteasome regulatory subunit 10B
Gene Name	PSMC6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
206	VSSSIVDKYIGESAR

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

Protein Sequence

10 MADPRDKALQ 20 DYRKKLLEHK 30 EIDGRLKELR 40 EQLKELTKQY 50 EKSENDLKAL 60 QSVGQIVGEV 70 LKQLTEEKFI 80 VKATNGPRYV 90 VGCRRQLDKS 100 KLKPGTRVAL 110 DMTTLTIMRY 120 LPREVDPLVY 130 NMSHEDPGNV 140 SYSEIGGLSE 150 QIRELREVIE 160 LPLTNPELFQ 170 RVGIIPPKGC 180 LLYGPPGTGK 190 TLLARAVASQ 200 LDCNFLKVVS 210 SSIVDKYIGE 220 SARLIREMFN 230 YARDHQPCII 240 FMDEIDAIGG 250 RRFSEGTSAD 260 REIQRTLMEL 270 LNQMDGFDTL 280 HRVKMIMATN 290 RPDTLDPALL 300 RPGRLDRKIH 310 IDLPNEQARL 320 DILKIHAGPI 330 TKHGEIDYEA 340 IVKLSDGFNG 350 ADLRNVCTEA 360 GMFAIRADHD 370 FVVQEDFMKA 380 VRKVADSKKL ESKLDYKPV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031597	cytosolic proteasome complex
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016234	inclusion body
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0022624	proteasome accessory complex
Cellular Component	GO:0000502	proteasome complex
Cellular Component	GO:0008540	proteasome regulatory particle, base subcomplex
Cellular Component	GO:0008021	synaptic vesicle
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0036402	proteasome-activating activity
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0071357	cellular response to type I interferon
Biological Process	GO:0036503	ERAD pathway
Biological Process	GO:0090261	positive regulation of inclusion body assembly
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process
Biological Process	GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process	GO:0010498	proteasomal protein catabolic process
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.