Search Results
Overview
| Uniprot ID | P62491 |
|---|---|
| Protein Name | Ras-related protein Rab-11A |
| Gene Name | RAB11A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | IYRIVSQKQMSDRRE |
| 61 | QVDGKTIKAQIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). Also interacts with RABL3 to promote ciliary vesicle formation (PubMed:36052645)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034451 | centriolar satellite |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0090307 | mitotic spindle assembly |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0098887 | neurotransmitter receptor transport, endosome to postsynaptic membrane |
| Biological Process | GO:0048227 | plasma membrane to endosome transport |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process | GO:1903438 | positive regulation of mitotic cytokinetic process |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:0061512 | protein localization to cilium |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:1902017 | regulation of cilium assembly |
| Biological Process | GO:0032465 | regulation of cytokinesis |
| Biological Process | GO:1902954 | regulation of early endosome to recycling endosome transport |
| Biological Process | GO:2001135 | regulation of endocytic recycling |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:1904779 | regulation of protein localization to centrosome |
| Biological Process | GO:0051223 | regulation of protein transport |
| Biological Process | GO:0060627 | regulation of vesicle-mediated transport |
| Biological Process | GO:0099532 | synaptic vesicle endosomal processing |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0098837 | postsynaptic recycling endosome |
| Cellular Component | GO:0098830 | presynaptic endosome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0000922 | spindle pole |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Cellular Component | GO:0030133 | transport vesicle |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0051959 | dynein light intermediate chain binding |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0031489 | myosin V binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Biological Process | GO:0150093 | amyloid-beta clearance by transcytosis |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0061502 | early endosome to recycling endosome transport |
| Biological Process | GO:0090150 | establishment of protein localization to membrane |
| Biological Process | GO:0072594 | establishment of protein localization to organelle |
| Biological Process | GO:0051650 | establishment of vesicle localization |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:1990182 | exosomal secretion |
| Biological Process | GO:0043001 | Golgi to plasma membrane protein transport |
| Biological Process | GO:0032402 | melanosome transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.