Search Results

Overview

Uniprot ID	P62631
Protein Name	Elongation factor 1-alpha 2
Gene Name	Eef1a2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
219	KGWKVERKEGNASGV
408	IVEMVPGKPMCVESF
439	TVAVGVIKNVEKKSG
44	RTIEKFEKEAAEMGK

Function

Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity)

Protein Sequence

10 MGKEKTHINI 20 VVIGHVDSGK 30 STTTGHLIYK 40 CGGIDKRTIE 50 KFEKEAAEMG 60 KGSFKYAWVL 70 DKLKAERERG 80 ITIDISLWKF 90 ETTKYYITII 100 DAPGHRDFIK 110 NMITGTSQAD 120 CAVLIVAAGV 130 GEFEAGISKN 140 GQTREHALLA 150 YTLGVKQLIV 160 GVNKMDSTEP 170 AYSEKRYDEI 180 VKEVSAYIKK 190 IGYNPATVPF 200 VPISGWHGDN 210 MLEPSPNMPW 220 FKGWKVERKE 230 GNASGVSLLE 240 ALDTILPPTR 250 PTDKPLRLPL 260 QDVYKIGGIG 270 TVPVGRVETG 280 ILRPGMVVTF 290 APVNITTEVK 300 SVEMHHEALS 310 EALPGDNVGF 320 NVKNVSVKDI 330 RRGNVCGDSK 340 ADPPQEAAQF 350 TSQVIILNHP 360 GQISAGYSPV 370 IDCHTAHIAC 380 KFAELKEKID 390 RRSGKKLEDN 400 PKSLKSGDAA 410 IVEMVPGKPM 420 CVESFSQYPP 430 LGRFAVRDMR 440 QTVAVGVIKN 450 VEKKSGGAGK 460 VTKSAQKAQK AGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005853	eukaryotic translation elongation factor 1 complex
Cellular Component	GO:0098982	GABA-ergic synapse
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0090218	positive regulation of lipid kinase activity
Biological Process	GO:0099150	regulation of postsynaptic specialization assembly
Biological Process	GO:0006412	translation
Biological Process	GO:0006414	translational elongation

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.