Overview
| Uniprot ID | P62632 |
|---|
| Protein Name | Elongation factor 1-alpha 2 |
|---|
| Gene Name | Eef1a2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 165 |
TEPAYSEKRYDEIVK |
| 439 |
TVAVGVIKNVEKKSG |
Function
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity)
Protein Sequence
10
MGKEKTHINI
20
VVIGHVDSGK
30
STTTGHLIYK
40
CGGIDKRTIE
50
KFEKEAAEMG
60
KGSFKYAWVL
70
DKLKAERERG
80
ITIDISLWKF
90
ETTKYYITII
100
DAPGHRDFIK
110
NMITGTSQAD
120
CAVLIVAAGV
130
GEFEAGISKN
140
GQTREHALLA
150
YTLGVKQLIV
160
GVNKMDSTEP
170
AYSEKRYDEI
180
VKEVSAYIKK
190
IGYNPATVPF
200
VPISGWHGDN
210
MLEPSPNMPW
220
FKGWKVERKE
230
GNASGVSLLE
240
ALDTILPPTR
250
PTDKPLRLPL
260
QDVYKIGGIG
270
TVPVGRVETG
280
ILRPGMVVTF
290
APVNITTEVK
300
SVEMHHEALS
310
EALPGDNVGF
320
NVKNVSVKDI
330
RRGNVCGDSK
340
ADPPQEAAQF
350
TSQVIILNHP
360
GQISAGYSPV
370
IDCHTAHIAC
380
KFAELKEKID
390
RRSGKKLEDN
400
PKSLKSGDAA
410
IVEMVPGKPM
420
CVESFSQYPP
430
LGRFAVRDMR
440
QTVAVGVIKN
450
VEKKSGGAGK
460
VTKSAQKAQK
AGK
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0006414 |
translational elongation |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005853 |
eukaryotic translation elongation factor 1 complex |
| Cellular Component |
GO:0098982 |
GABA-ergic synapse |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0003746 |
translation elongation factor activity |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0090218 |
positive regulation of lipid kinase activity |
| Biological Process |
GO:0099150 |
regulation of postsynaptic specialization assembly |
| Biological Process |
GO:0051602 |
response to electrical stimulus |
| Biological Process |
GO:0006412 |
translation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.