Search Results

Overview

Uniprot IDP62633
Protein NameCCHC-type zinc finger nucleic acid binding protein
Gene NameCNBP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 QCCYNCGKPGHLARD
130 GEFGHIQKDCTKVKC
8 MSSNECFKCGRSGHW

Function

Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity)

Protein Sequence

10 MSSNECFKCG 20 RSGHWARECP 30 TGGGRGRGMR 40 SRGRGGFTSD 50 RGFQFVSSSL 60 PDICYRCGES 70 GHLAKDCDLQ 80 EDACYNCGRG 90 GHIAKDCKEP 100 KREREQCCYN 110 CGKPGHLARD 120 CDHADEQKCY 130 SCGEFGHIQK 140 DCTKVKCYRC 150 GETGHVAINC 160 SKTSEVNCYR 170 CGESGHLARE CTIEATA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Molecular Function GO:0051880 G-quadruplex DNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003727 single-stranded RNA binding
Molecular Function GO:0045182 translation regulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0071919 G-quadruplex DNA formation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.