Search Results

Overview

Uniprot IDP62701
Protein NameSmall ribosomal subunit protein eS4, X isoform
Gene NameRPS4X
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 FRLIYDTKGRFAVHR
128 YKLCKVRKIFVGTKG
134 RKIFVGTKGIPHLVT
16 LKRVAAPKHWMLDKL
233 FVIGKGNKPWISLPR
37 RPSTGPHKLRECLPL
53 IFLRNRLKYALTGDE
62 ALTGDEVKKICMQRF
63 LTGDEVKKICMQRFI
71 ICMQRFIKIDGKVRT

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MARGPKKHLK 20 RVAAPKHWML 30 DKLTGVFAPR 40 PSTGPHKLRE 50 CLPLIIFLRN 60 RLKYALTGDE 70 VKKICMQRFI 80 KIDGKVRTDI 90 TYPAGFMDVI 100 SIDKTGENFR 110 LIYDTKGRFA 120 VHRITPEEAK 130 YKLCKVRKIF 140 VGTKGIPHLV 150 THDARTIRYP 160 DPLIKVNDTI 170 QIDLETGKIT 180 DFIKFDTGNL 190 CMVTGGANLG 200 RIGVITNRER 210 HPGSFDVVHV 220 KDANGNSFAT 230 RLSNIFVIGK 240 GNKPWISLPR 250 GKGIRLTIAE 260 ERDKRLAAKQ SSG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0022626 cytosolic ribosome
Cellular Component GO:0022627 cytosolic small ribosomal subunit
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005840 ribosome
Cellular Component GO:0015935 small ribosomal subunit
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0019843 rRNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006412 translation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.