Overview
| Uniprot ID | P62716 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
|---|
| Gene Name | Ppp2cb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 41 |
KAKEILTKESNVQEV |
Function
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation
Protein Sequence
10
MDDKAFTKEL
20
DQWVEQLNEC
30
KQLNENQVRT
40
LCEKAKEILT
50
KESNVQEVRC
60
PVTVCGDVHG
70
QFHDLMELFR
80
IGGKSPDTNY
90
LFMGDYVDRG
100
YYSVETVTLL
110
VALKVRYPER
120
ITILRGNHES
130
RQITQVYGFY
140
DECLRKYGNA
150
NVWKYFTDLF
160
DYLPLTALVD
170
GQIFCLHGGL
180
SPSIDTLDHI
190
RALDRLQEVP
200
HEGPMCDLLW
210
SDPDDRGGWG
220
ISPRGAGYTF
230
GQDISETFNH
240
ANGLTLVSRA
250
HQLVMEGYNW
260
CHDRNVVTIF
270
SAPNYCYRCG
280
NQAAIMELDD
290
TLKYSFLQFD
300
PAPRRGEPHV
TRRTPDYFL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0090443 |
FAR/SIN/STRIPAK complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000159 |
protein phosphatase type 2A complex |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004721 |
phosphoprotein phosphatase activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0044325 |
transmembrane transporter binding |
| Biological Process |
GO:0008637 |
apoptotic mitochondrial changes |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0043124 |
negative regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0046580 |
negative regulation of Ras protein signal transduction |
| Biological Process |
GO:0010804 |
negative regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0006470 |
protein dephosphorylation |
| Biological Process |
GO:0010468 |
regulation of gene expression |
| Biological Process |
GO:0031113 |
regulation of microtubule polymerization |
| Biological Process |
GO:0046677 |
response to antibiotic |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0042542 |
response to hydrogen peroxide |
| Biological Process |
GO:0010288 |
response to lead ion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.