Search Results
Overview
| Uniprot ID | P62737 |
|---|---|
| Protein Name | Actin, aortic smooth muscle |
| Gene Name | Acta2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | TEAPLNPKANREKMT |
| 317 | GIADRMQKEITALAP |
| 328 | ALAPSTMKIKIIAPP |
| 330 | APSTMKIKIIAPPER |
| 52 | VMVGMGQKDSYVGDE |
| 63 | VGDEAQSKRGILTLK |
Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells
Protein Sequence
10
MCEEEDSTAL
20
VCDNGSGLCK
30
AGFAGDDAPR
40
AVFPSIVGRP
50
RHQGVMVGMG
60
QKDSYVGDEA
70
QSKRGILTLK
80
YPIEHGIITN
90
WDDMEKIWHH
100
SFYNELRVAP
110
EEHPTLLTEA
120
PLNPKANREK
130
MTQIMFETFN
140
VPAMYVAIQA
150
VLSLYASGRT
160
TGIVLDSGDG
170
VTHNVPIYEG
180
YALPHAIMRL
190
DLAGRDLTDY
200
LMKILTERGY
210
SFVTTAEREI
220
VRDIKEKLCY
230
VALDFENEMA
240
TAASSSSLEK
250
SYELPDGQVI
260
TIGNERFRCP
270
ETLFQPSFIG
280
MESAGIHETT
290
YNSIMKCDID
300
IRKDLYANNV
310
LSGGTTMYPG
320
IADRMQKEIT
330
ALAPSTMKIK
340
IIAPPERKYS
350
VWIGGSILAS
360
LSTFQQMWIS
370
KQEYDEAGPS
IVHRKCF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0030485 | smooth muscle contractile fiber |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0072144 | glomerular mesangial cell development |
| Biological Process | GO:0072051 | juxtaglomerular apparatus development |
| Biological Process | GO:0090131 | mesenchyme migration |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:2000491 | positive regulation of hepatic stellate cell activation |
| Biological Process | GO:0061874 | positive regulation of hepatic stellate cell contraction |
| Biological Process | GO:0061870 | positive regulation of hepatic stellate cell migration |
| Biological Process | GO:0008217 | regulation of blood pressure |
| Biological Process | GO:0009615 | response to virus |
| Biological Process | GO:0014829 | vascular associated smooth muscle contraction |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.