Overview
| Uniprot ID | P62745 |
|---|
| Protein Name | Rho-related GTP-binding protein RhoB |
|---|
| Gene Name | RHOB |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 135 |
RTELARMKQEPVRTD |
Function
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells
Protein Sequence
10
MAAIRKKLVV
20
VGDGACGKTC
30
LLIVFSKDEF
40
PEVYVPTVFE
50
NYVADIEVDG
60
KQVELALWDT
70
AGQEDYDRLR
80
PLSYPDTDVI
90
LMCFSVDSPD
100
SLENIPEKWV
110
PEVKHFCPNV
120
PIILVANKKD
130
LRSDEHVRTE
140
LARMKQEPVR
150
TDDGRAMAVR
160
IQAYDYLECS
170
AKTKEGVREV
180
FETATRAALQ
190
KRYGSQNGCI
NCCKVL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0032154 |
cleavage furrow |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0031902 |
late endosome membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0070301 |
cellular response to hydrogen peroxide |
| Biological Process |
GO:0071479 |
cellular response to ionizing radiation |
| Biological Process |
GO:0008333 |
endosome to lysosome transport |
| Biological Process |
GO:0061154 |
endothelial tube morphogenesis |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0045786 |
negative regulation of cell cycle |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0045766 |
positive regulation of angiogenesis |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0010595 |
positive regulation of endothelial cell migration |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0030334 |
regulation of cell migration |
| Biological Process |
GO:0099159 |
regulation of modification of postsynaptic structure |
| Biological Process |
GO:0007266 |
Rho protein signal transduction |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.