Search Results
Overview
| Uniprot ID | P62747 |
|---|---|
| Protein Name | Rho-related GTP-binding protein RhoB |
| Gene Name | Rhob |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | PIILVANKKDLRSDE |
| 135 | RTELARMKQEPVRTD |
| 162 | DYLECSAKTKEGVRE |
Function
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071479 | cellular response to ionizing radiation |
| Biological Process | GO:0008333 | endosome to lysosome transport |
| Biological Process | GO:0061154 | endothelial tube morphogenesis |
| Biological Process | GO:0000281 | mitotic cytokinesis |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0099159 | regulation of modification of postsynaptic structure |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.