Search Results
Overview
| Uniprot ID | P62751 |
|---|---|
| Protein Name | Large ribosomal subunit protein uL23 |
| Gene Name | Rpl23a |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | KEAPAPPKAEAKAKA |
| 7 | *MAPKAKKEAPAPPK |
Function
Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity)
Protein Sequence
10
MAPKAKKEAP
20
APPKAEAKAK
30
ALKAKKAVLK
40
GVHSHKKKKI
50
RTSPTFRRPK
60
TLRLRRQPKY
70
PRKSAPRRNK
80
LDHYAIIKFP
90
LTTESAMKKI
100
EDNNTLVFIV
110
DVKANKHQIK
120
QAVKKLYDID
130
VAKVNTLIRP
140
DGEKKAYVRL
150
APDYDALDVA
NKIGII
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0022625 | cytosolic large ribosomal subunit |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0070180 | large ribosomal subunit rRNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Molecular Function | GO:1904841 | TORC2 complex binding |
| Biological Process | GO:0002181 | cytoplasmic translation |
| Biological Process | GO:1901740 | negative regulation of myoblast fusion |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0006941 | striated muscle contraction |
| Biological Process | GO:0140242 | translation at postsynapse |
| Biological Process | GO:0140236 | translation at presynapse |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.