Search Results
Overview
| Uniprot ID | P62753 |
|---|---|
| Protein Name | Small ribosomal subunit protein eS6 |
| Gene Name | RPS6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | FPATGCQKLIEVDDE |
| 143 | KRASRIRKLFNLSKE |
| 149 | RKLFNLSKEDDVRQY |
| 2 | ******MKLNISFPA |
| 203 | KQRTKKNKEEAAEYA |
| 211 | EEAAEYAKLLAKRMK |
| 64 | DKQGFPMKQGVLTHG |
| 79 | RVRLLLSKGHSCYRP |
Function
Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0015935 | small ribosomal subunit |
| Cellular Component | GO:0032040 | small-subunit processome |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003735 | structural constituent of ribosome |
| Biological Process | GO:0071361 | cellular response to ethanol |
| Biological Process | GO:0002181 | cytoplasmic translation |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:1903347 | negative regulation of bicellular tight junction assembly |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0000028 | ribosomal small subunit assembly |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0006364 | rRNA processing |
| Biological Process | GO:0031929 | TOR signaling |
| Biological Process | GO:0006412 | translation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.