Search Results
Overview
| Uniprot ID | P62775 |
|---|---|
| Protein Name | Myotrophin |
| Gene Name | Mtpn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | EVKDYVAKGEDVNRT |
| 90 | CVKLLLSKGADKTVK |
Function
Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0021707 | cerebellar granule cell differentiation |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0010557 | positive regulation of macromolecule biosynthetic process |
| Biological Process | GO:0051247 | positive regulation of protein metabolic process |
| Biological Process | GO:2000812 | regulation of barbed-end actin filament capping |
| Biological Process | GO:0008361 | regulation of cell size |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0051146 | striated muscle cell differentiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.