Search Results
Overview
| Uniprot ID | P62806 |
|---|---|
| Protein Name | Histone H4 |
| Gene Name | H4c1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 32 | DNIQGITKPAIRRLA |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MSGRGKGGKG
20
LGKGGAKRHR
30
KVLRDNIQGI
40
TKPAIRRLAR
50
RGGVKRISGL
60
IYEETRGVLK
70
VFLENVIRDA
80
VTYTEHAKRK
90
TVTAMDVVYA
100
LKRQGRTLYG
FGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043505 | CENP-A containing nucleosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0061644 | protein localization to CENP-A containing chromatin |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.