Search Results
Overview
| Uniprot ID | P62820 |
|---|---|
| Protein Name | Ras-related protein Rab-1A |
| Gene Name | RAB1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | YASENVNKLLVGNKC |
| 125 | NKLLVGNKCDLTTKK |
| 132 | KCDLTTKKVVDYTTA |
| 187 | ATAGGAEKSNVKIQS |
| 191 | GAEKSNVKIQSTPVK |
| 58 | RTIELDGKTIKLQIW |
| 61 | ELDGKTIKLQIWDTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:20861236, PubMed:21303926, PubMed:22939626). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (PubMed:21303926). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Regulates the level of CASR present at the cell membrane (PubMed:20861236). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (PubMed:22939626). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0030658 | transport vesicle membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0000045 | autophagosome assembly |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0090110 | COPII-coated vesicle cargo loading |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0030252 | growth hormone secretion |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0032402 | melanosome transport |
| Biological Process | GO:1903020 | positive regulation of glycoprotein metabolic process |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
| Biological Process | GO:0047496 | vesicle transport along microtubule |
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Biological Process | GO:0019068 | virion assembly |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.
[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.