Search Results
Overview
| Uniprot ID | P62826 |
|---|---|
| Protein Name | GTP-binding nuclear protein Ran |
| Gene Name | RAN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 123 | PIVLCGNKVDIKDRK |
| 127 | CGNKVDIKDRKVKAK |
| 134 | KDRKVKAKSIVFHRK |
| 141 | KSIVFHRKKNLQYYD |
| 142 | SIVFHRKKNLQYYDI |
| 23 | VGDGGTGKTTFVKRH |
| 37 | HLTGEFEKKYVATLG |
| 38 | LTGEFEKKYVATLGV |
| 60 | HTNRGPIKFNVWDTA |
| 71 | WDTAGQEKFGGLRDG |
| 99 | VTSRVTYKNVPNWHR |
Function
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0001673 | male germ cell nucleus |
| Cellular Component | GO:0002177 | manchette |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0055037 | recycling endosome |
| Cellular Component | GO:0042565 | RNA nuclear export complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0045505 | dynein intermediate chain binding |
| Molecular Function | GO:0003925 | G protein activity |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0061676 | importin-alpha family protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0071389 | cellular response to mineralocorticoid stimulus |
| Biological Process | GO:0006259 | DNA metabolic process |
| Biological Process | GO:0046039 | GTP metabolic process |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0000070 | mitotic sister chromatid segregation |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0035281 | pre-miRNA export from nucleus |
| Biological Process | GO:0006611 | protein export from nucleus |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:1902570 | protein localization to nucleolus |
| Biological Process | GO:0000055 | ribosomal large subunit export from nucleus |
| Biological Process | GO:0000056 | ribosomal small subunit export from nucleus |
| Biological Process | GO:0000054 | ribosomal subunit export from nucleus |
| Biological Process | GO:0061015 | snRNA import into nucleus |
| Biological Process | GO:0007286 | spermatid development |
| Biological Process | GO:0016032 | viral process |
Reference
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