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Overview

Uniprot IDP62834
Protein NameRas-related protein Rap-1A
Gene NameRAP1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 EDERVVGKEQGQNLA

Function

Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions

Protein Sequence

10 MREYKLVVLG 20 SGGVGKSALT 30 VQFVQGIFVE 40 KYDPTIEDSY 50 RKQVEVDCQQ 60 CMLEILDTAG 70 TEQFTAMRDL 80 YMKNGQGFAL 90 VYSITAQSTF 100 NDLQDLREQI 110 LRVKDTEDVP 120 MILVGNKCDL 130 EDERVVGKEQ 140 GQNLARQWCN 150 CAFLESSAKS 160 KINVNEIFYD 170 LVRQINRKTP 180 VEKKKPKKKS CLLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070161 anchoring junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031045 dense core granule
Cellular Component GO:0005769 early endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0032045 guanyl-nucleotide exchange factor complex
Cellular Component GO:0005770 late endosome
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0035579 specific granule membrane
Cellular Component GO:0097225 sperm midpiece
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:1904322 cellular response to forskolin
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0061028 establishment of endothelial barrier
Biological Process GO:0030073 insulin secretion
Biological Process GO:0097421 liver regeneration
Biological Process GO:0032966 negative regulation of collagen biosynthetic process
Biological Process GO:2000301 negative regulation of synaptic vesicle exocytosis
Biological Process GO:0038180 nerve growth factor signaling pathway
Biological Process GO:0007399 nervous system development
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:2001214 positive regulation of vasculogenesis
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0032486 Rap protein signal transduction
Biological Process GO:1901888 regulation of cell junction assembly
Biological Process GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Biological Process GO:0097327 response to antineoplastic agent
Biological Process GO:0009743 response to carbohydrate

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.