Search Results

Overview

Uniprot IDP62873
Protein NameGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Gene NameGNB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
15 RQEAEQLKNQIRDAR
209 GACDASAKLWDVREG
23 NQIRDARKACADATL

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:37991948, PubMed:38168118, PubMed:38552625, PubMed:39103320). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625, PubMed:39103320)

Protein Sequence

10 MSELDQLRQE 20 AEQLKNQIRD 30 ARKACADATL 40 SQITNNIDPV 50 GRIQMRTRRT 60 LRGHLAKIYA 70 MHWGTDSRLL 80 VSASQDGKLI 90 IWDSYTTNKV 100 HAIPLRSSWV 110 MTCAYAPSGN 120 YVACGGLDNI 130 CSIYNLKTRE 140 GNVRVSRELA 150 GHTGYLSCCR 160 FLDDNQIVTS 170 SGDTTCALWD 180 IETGQQTTTF 190 TGHTGDVMSL 200 SLAPDTRLFV 210 SGACDASAKL 220 WDVREGMCRQ 230 TFTGHESDIN 240 AICFFPNGNA 250 FATGSDDATC 260 RLFDLRADQE 270 LMTYSHDNII 280 CGITSVSFSK 290 SGRLLLAGYD 300 DFNCNVWDAL 310 KADRAGVLAG 320 HDNRVSCLGV 330 TDDGMAVATG 340 SWDSFLKIWN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005834 heterotrimeric G-protein complex
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0097381 photoreceptor disc membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Biological Process GO:0071870 cellular response to catecholamine stimulus
Biological Process GO:0071380 cellular response to prostaglandin E stimulus
Biological Process GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007265 Ras protein signal transduction
Biological Process GO:0007165 signal transduction

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.