Search Results
Overview
| Uniprot ID | P62879 |
|---|---|
| Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 |
| Gene Name | GNB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 23 | NQIRDARKACGDSTL |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Protein Sequence
10
MSELEQLRQE
20
AEQLRNQIRD
30
ARKACGDSTL
40
TQITAGLDPV
50
GRIQMRTRRT
60
LRGHLAKIYA
70
MHWGTDSRLL
80
VSASQDGKLI
90
IWDSYTTNKV
100
HAIPLRSSWV
110
MTCAYAPSGN
120
FVACGGLDNI
130
CSIYSLKTRE
140
GNVRVSRELP
150
GHTGYLSCCR
160
FLDDNQIITS
170
SGDTTCALWD
180
IETGQQTVGF
190
AGHSGDVMSL
200
SLAPDGRTFV
210
SGACDASIKL
220
WDVRDSMCRQ
230
TFIGHESDIN
240
AVAFFPNGYA
250
FTTGSDDATC
260
RLFDLRADQE
270
LLMYSHDNII
280
CGITSVAFSR
290
SGRLLLAGYD
300
DFNCNIWDAM
310
KGDRAGVLAG
320
HDNRVSCLGV
330
TDDGMAVATG
340
SWDSFLKIWN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0003924 | GTPase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005834 | heterotrimeric G-protein complex |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0051020 | GTPase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:1901379 | regulation of potassium ion transmembrane transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.