Overview
| Uniprot ID | P62882 |
|---|
| Protein Name | Guanine nucleotide-binding protein subunit beta-5 |
|---|
| Gene Name | Gnb5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 32 |
KLEEERAKLHDVELH |
Function
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity)
Protein Sequence
10
MATDGLHENE
20
TLASLKSEAE
30
SLKGKLEEER
40
AKLHDVELHQ
50
VAERVEALGQ
60
FVMKTRRTLK
70
GHGNKVLCMD
80
WCKDKRRIVS
90
SSQDGKVIVW
100
DSFTTNKEHA
110
VTMPCTWVMA
120
CAYAPSGCAI
130
ACGGLDNKCS
140
VYPLTFDKNE
150
NMAAKKKSVA
160
MHTNYLSACS
170
FTNSDMQILT
180
ASGDGTCALW
190
DVESGQLLQS
200
FHGHGADVLC
210
LDLAPSETGN
220
TFVSGGCDKK
230
AMVWDMRSGQ
240
CVQAFETHES
250
DVNSVRYYPS
260
GDAFASGSDD
270
ATCRLYDLRA
280
DREVAIYSKE
290
SIIFGASSVD
300
FSLSGRLLFA
310
GYNDYTINVW
320
DVLKGSRVSI
330
LFGHENRVST
340
LRVSPDGTAF
350
CSGSWDHTLR
VWA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0044297 |
cell body |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005834 |
heterotrimeric G-protein complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098688 |
parallel fiber to Purkinje cell synapse |
| Cellular Component |
GO:0001917 |
photoreceptor inner segment |
| Cellular Component |
GO:0001750 |
photoreceptor outer segment |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0031682 |
G-protein gamma-subunit binding |
| Molecular Function |
GO:0032794 |
GTPase activating protein binding |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0051087 |
protein-folding chaperone binding |
| Molecular Function |
GO:0030159 |
signaling receptor complex adaptor activity |
| Biological Process |
GO:1990603 |
dark adaptation |
| Biological Process |
GO:0007212 |
G protein-coupled dopamine receptor signaling pathway |
| Biological Process |
GO:0007186 |
G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0036367 |
light adaption |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.