Search Results
Overview
| Uniprot ID | P62937 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase A |
| Gene Name | PPIA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | QFFICTAKTEWLDGK |
| 125 | KTEWLDGKHVVFGKV |
| 131 | GKHVVFGKVKEGMNI |
| 133 | HVVFGKVKEGMNIVE |
| 155 | RNGKTSKKITIADCG |
| 28 | SFELFADKVPKTAEN |
| 31 | LFADKVPKTAENFRA |
| 44 | RALSTGEKGFGYKGS |
| 49 | GEKGFGYKGSCFHRI |
| 76 | RHNGTGGKSIYGEKF |
| 82 | GKSIYGEKFEDENFI |
Function
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0030595 | leukocyte chemotaxis |
| Biological Process | GO:0034389 | lipid droplet organization |
| Biological Process | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0061944 | negative regulation of protein K48-linked ubiquitination |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0001933 | negative regulation of protein phosphorylation |
| Biological Process | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| Biological Process | GO:1903901 | negative regulation of viral life cycle |
| Biological Process | GO:0030593 | neutrophil chemotaxis |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0050714 | positive regulation of protein secretion |
| Biological Process | GO:0045070 | positive regulation of viral genome replication |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0000413 | protein peptidyl-prolyl isomerization |
| Biological Process | GO:2001233 | regulation of apoptotic signaling pathway |
| Biological Process | GO:0045069 | regulation of viral genome replication |
| Biological Process | GO:0019076 | viral release from host cell |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0016018 | cyclosporin A binding |
| Molecular Function | GO:1904399 | heparan sulfate binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0046790 | virion binding |
| Biological Process | GO:0032148 | activation of protein kinase B activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0060352 | cell adhesion molecule production |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0042118 | endothelial cell activation |
Reference
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[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
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[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.