Search Results
Overview
| Uniprot ID | P62942 |
|---|---|
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP1A |
| Gene Name | FKBP1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | PFKFMLGKQEVIRGW |
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098562 | cytoplasmic side of membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:1990425 | ryanodine receptor complex |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0014802 | terminal cisterna |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0070697 | activin receptor binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0005528 | FK506 binding |
| Molecular Function | GO:0070411 | I-SMAD binding |
| Molecular Function | GO:0005527 | macrolide binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0030547 | signaling receptor inhibitor activity |
| Molecular Function | GO:0005160 | transforming growth factor beta receptor binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0034713 | type I transforming growth factor beta receptor binding |
| Biological Process | GO:0006458 | 'de novo' protein folding |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0032926 | negative regulation of activin receptor signaling pathway |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:1902991 | regulation of amyloid precursor protein catabolic process |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0050776 | regulation of immune response |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:0097435 | supramolecular fiber organization |
| Biological Process | GO:0042110 | T cell activation |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.