Search Results
Overview
| Uniprot ID | P62963 |
|---|---|
| Protein Name | Profilin-1 |
| Gene Name | Pfn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 126 | VHGGLINKKCYEMAS |
| 127 | HGGLINKKCYEMASH |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)
Protein Sequence
10
MAGWNAYIDS
20
LMADGTCQDA
30
AIVGYKDSPS
40
VWAAVPGKTF
50
VSITPAEVGV
60
LVGKDRSSFF
70
VNGLTLGGQK
80
CSVIRDSLLQ
90
DGEFTMDLRT
100
KSTGGAPTFN
110
VTVTMTAKTL
120
VLLMGKEGVH
130
GGLINKKCYE
140
MASHLRRSQY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0032232 | negative regulation of actin filament bundle assembly |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:0001843 | neural tube closure |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0051054 | positive regulation of DNA metabolic process |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0050434 | positive regulation of viral transcription |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:1904772 | response to tetrachloromethane |
| Biological Process | GO:0060074 | synapse maturation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.