Search Results
Overview
| Uniprot ID | P62997 |
|---|---|
| Protein Name | Transformer-2 protein homolog beta |
| Gene Name | Tra2b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 197 | RVDFSITKRPHTPTP |
Function
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity)
Protein Sequence
10
MSDSGEQNYG
20
ERESRSASRS
30
GSAHGSGKSA
40
RHTPARSRSK
50
EDSRRSRSKS
60
RSRSESRSRS
70
RRSSRRHYTR
80
SRSRSRSHRR
90
SRSRSYSRDY
100
RRRHSHSHSP
110
MSTRRRHVGN
120
RANPDPNCCL
130
GVFGLSLYTT
140
ERDLREVFSK
150
YGPIADVSIV
160
YDQQSRRSRG
170
FAFVYFENVD
180
DAKEAKERAN
190
GMELDGRRIR
200
VDFSITKRPH
210
TPTPGIYMGR
220
PTYGSSRRRD
230
YYDRGYDRGY
240
DDRDYYSRSY
250
RGGGGGGGGW
260
RAAQDRDQIY
270
RRRSPSPYYS
280
RGGYRSRSRS
RSYSPRRY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0070717 | poly-purine tract binding |
| Molecular Function | GO:0036002 | pre-mRNA binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0021796 | cerebral cortex regionalization |
| Biological Process | GO:1990403 | embryonic brain development |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0048026 | positive regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0043484 | regulation of RNA splicing |
| Biological Process | GO:0000302 | response to reactive oxygen species |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.