Search Results

Overview

Uniprot IDP63027
Protein NameVesicle-associated membrane protein 2
Gene NameVAMP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
52 IMRVNVDKVLERDQK
83 QFETSAAKLKRKYWW

Function

SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:10036234, PubMed:30929742). VAMP2 is a v-SNARE assembling into a SNARE complex with the t-SNAREs SNAP25 and STX1A to mediate the fusion of synaptic vesicles with the presynaptic plasma membrane in neurotransmitter release (PubMed:30929742). Also functions in compensatory endocytosis for synaptic vesicle recycling (By similarity). In adipocytes, it is involved in the insulin-dependent exocytosis of GLUT4 storage vesicles (By similarity). Independently of its SNARE activity, it could modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity)

Protein Sequence

10 MSATAATAPP 20 AAPAGEGGPP 30 APPPNLTSNR 40 RLQQTQAQVD 50 EVVDIMRVNV 60 DKVLERDQKL 70 SELDDRADAL 80 QAGASQFETS 90 AAKLKRKYWW 100 KNLKMMIILG 110 VICAIILIII IVYFST

Gene Ontology

Classification GO ID Description
Cellular Component GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
Cellular Component GO:0060203 clathrin-sculpted glutamate transport vesicle membrane
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0044306 neuron projection terminus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0030141 secretory granule
Cellular Component GO:0030667 secretory granule membrane
Cellular Component GO:0031201 SNARE complex
Cellular Component GO:0045202 synapse
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
Cellular Component GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Cellular Component GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Cellular Component GO:0005802 trans-Golgi network
Cellular Component GO:0031982 vesicle
Cellular Component GO:0042589 zymogen granule membrane
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0005484 SNAP receptor activity
Molecular Function GO:0000149 SNARE binding
Molecular Function GO:0019905 syntaxin binding
Molecular Function GO:0017075 syntaxin-1 binding
Biological Process GO:0017156 calcium-ion regulated exocytosis
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0043308 eosinophil degranulation
Biological Process GO:0006887 exocytosis
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0061025 membrane fusion
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0015031 protein transport
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:1902259 regulation of delayed rectifier potassium channel activity
Biological Process GO:0017157 regulation of exocytosis
Biological Process GO:0060627 regulation of vesicle-mediated transport
Biological Process GO:0009749 response to glucose
Biological Process GO:0035493 SNARE complex assembly
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016079 synaptic vesicle exocytosis
Biological Process GO:0006906 vesicle fusion
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.