Search Results
Overview
| Uniprot ID | P63031 |
|---|---|
| Protein Name | Mitochondrial pyruvate carrier 1 |
| Gene Name | Mpc1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MAGALVRKAADYVRS |
Function
Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (By similarity). Plays an essential role in cellular metabolism (By similarity)
Protein Sequence
10
MAGALVRKAA
20
DYVRSKDFRD
30
YLMSTHFWGP
40
VANWGLPIAA
50
INDMKKSPEI
60
ISGRMTFALC
70
CYSLTFMRFA
80
YKVQPRNWLL
90
FACHVTNEVA
100
QLIQGGRLIN
YEMSKRPSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
| Biological Process | GO:0006850 | pyruvate import into mitochondria |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.