Search Results
Overview
| Uniprot ID | P63041 |
|---|---|
| Protein Name | Complexin-1 |
| Gene Name | Cplx1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | MLGGDEEKDPDAAKK |
| 54 | ERKAKYAKMEAEREV |
| 6 | **MEFVMKQALGGAT |
Function
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Biological Process | GO:0030073 | insulin secretion |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0099145 | regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane |
| Biological Process | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.