Search Results
Overview
| Uniprot ID | P63045 |
|---|---|
| Protein Name | Vesicle-associated membrane protein 2 |
| Gene Name | Vamp2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | IMRVNVDKVLERDQK |
| 59 | KVLERDQKLSELDDR |
Function
SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:12496247, PubMed:19690160, PubMed:9759724). VAMP2 is a v-SNARE assembling into a SNARE complex with the t-SNAREs SNAP25 and STX1A to mediate the fusion of synaptic vesicles with the presynaptic plasma membrane in neurotransmitter release (PubMed:1331807). Also functions in compensatory endocytosis for synaptic vesicle recycling (By similarity). In adipocytes, it is involved in the insulin-dependent exocytosis of GLUT4 storage vesicles (By similarity). Independently of its SNARE activity, it could modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19690160)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0031201 | SNARE complex |
| Cellular Component | GO:0000322 | storage vacuole |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex |
| Cellular Component | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| Cellular Component | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| Cellular Component | GO:0043195 | terminal bouton |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0042589 | zymogen granule membrane |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0017022 | myosin binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0005484 | SNAP receptor activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Molecular Function | GO:0017075 | syntaxin-1 binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0017156 | calcium-ion regulated exocytosis |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0043308 | eosinophil degranulation |
| Biological Process | GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane |
| Biological Process | GO:0043001 | Golgi to plasma membrane protein transport |
| Biological Process | GO:0046879 | hormone secretion |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0061025 | membrane fusion |
| Biological Process | GO:0090316 | positive regulation of intracellular protein transport |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0045055 | regulated exocytosis |
| Biological Process | GO:1902259 | regulation of delayed rectifier potassium channel activity |
| Biological Process | GO:0017157 | regulation of exocytosis |
| Biological Process | GO:1903421 | regulation of synaptic vesicle recycling |
| Biological Process | GO:0060627 | regulation of vesicle-mediated transport |
| Biological Process | GO:0070723 | response to cholesterol |
| Biological Process | GO:0009749 | response to glucose |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0016081 | synaptic vesicle docking |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0006906 | vesicle fusion |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.