Overview
| Uniprot ID | P63088 |
|---|
| Protein Name | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
|---|
| Gene Name | Ppp1cc |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 319 |
PPRGMITKQAKK*** |
Function
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Regulates the recruitment of the SKA complex to kinetochores (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). Dephosphorylates MKI67 at the onset of anaphase (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)
Protein Sequence
10
MADIDKLNID
20
SIIQRLLEVR
30
GSKPGKNVQL
40
QENEIRGLCL
50
KSREIFLSQP
60
ILLELEAPLK
70
ICGDIHGQYY
80
DLLRLFEYGG
90
FPPESNYLFL
100
GDYVDRGKQS
110
LETICLLLAY
120
KIKYPENFFL
130
LRGNHECASI
140
NRIYGFYDEC
150
KRRYNIKLWK
160
TFTDCFNCLP
170
IAAIVDEKIF
180
CCHGGLSPDL
190
QSMEQIRRIM
200
RPTDVPDQGL
210
LCDLLWSDPD
220
KDVLGWGEND
230
RGVSFTFGAE
240
VVAKFLHKHD
250
LDLICRAHQV
260
VEDGYEFFAK
270
RQLVTLFSAP
280
NYCGEFDNAG
290
AMMSVDETLM
300
CSFQILKPAE
310
KKKPNATRPV
320
TPPRGMITKQ
AKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0098794 |
postsynapse |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0032154 |
cleavage furrow |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0000776 |
kinetochore |
| Cellular Component |
GO:0005815 |
microtubule organizing center |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0000164 |
protein phosphatase type 1 complex |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0072357 |
PTW/PP1 phosphatase complex |
| Molecular Function |
GO:0005521 |
lamin binding |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0016791 |
phosphatase activity |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0008157 |
protein phosphatase 1 binding |
| Molecular Function |
GO:0019903 |
protein phosphatase binding |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Biological Process |
GO:0001824 |
blastocyst development |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0032922 |
circadian regulation of gene expression |
| Biological Process |
GO:0043153 |
entrainment of circadian clock by photoperiod |
| Biological Process |
GO:0005977 |
glycogen metabolic process |
| Biological Process |
GO:0030182 |
neuron differentiation |
| Biological Process |
GO:0060252 |
positive regulation of glial cell proliferation |
| Biological Process |
GO:0006470 |
protein dephosphorylation |
| Biological Process |
GO:0042752 |
regulation of circadian rhythm |
| Biological Process |
GO:0046822 |
regulation of nucleocytoplasmic transport |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.