Search Results
Overview
| Uniprot ID | P63098 |
|---|---|
| Protein Name | Calcineurin subunit B type 1 |
| Gene Name | PPP3R1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 85 | GVSQFSVKGDKEQKL |
Function
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity
Protein Sequence
10
MGNEASYPLE
20
MCSHFDADEI
30
KRLGKRFKKL
40
DLDNSGSLSV
50
EEFMSLPELQ
60
QNPLVQRVID
70
IFDTDGNGEV
80
DFKEFIEGVS
90
QFSVKGDKEQ
100
KLRFAFRIYD
110
MDKDGYISNG
120
ELFQVLKMMV
130
GNNLKDTQLQ
140
QIVDKTIINA
150
DKDGDGRISF
160
EEFCAVVGGL
170
DIHKKMVVDV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005955 | calcineurin complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity |
| Molecular Function | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0033173 | calcineurin-NFAT signaling cascade |
| Biological Process | GO:1905949 | negative regulation of calcium ion import across plasma membrane |
| Biological Process | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:1905665 | positive regulation of calcium ion import across plasma membrane |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.