Search Results
Overview
| Uniprot ID | P63102 |
|---|---|
| Protein Name | 14-3-3 protein zeta/delta |
| Gene Name | Ywhaz |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | NELVQKAKLAEQAER |
| 122 | KVFYLKMKGDYYRYL |
| 138 | EVAAGDDKKGIVDQS |
| 158 | EAFEISKKEMQPTHP |
| 3 | *****MDKNELVQKA |
| 49 | NLLSVAYKNVVGARR |
| 68 | VVSSIEQKTEGAEKK |
| 85 | MAREYREKIETELRD |
| 9 | DKNELVQKAKLAEQA |
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (By similarity). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (PubMed:16959763)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0003016 | respiratory system process |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0008039 | synaptic target recognition |
| Biological Process | GO:0035148 | tube formation |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0099572 | postsynaptic specialization |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050815 | phosphoserine residue binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
| Biological Process | GO:0051683 | establishment of Golgi localization |
| Biological Process | GO:0090168 | Golgi reassembly |
| Biological Process | GO:0002553 | histamine secretion by mast cell |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0045824 | negative regulation of innate immune response |
| Biological Process | GO:1900181 | negative regulation of protein localization to nucleus |
| Biological Process | GO:1904262 | negative regulation of TORC1 signaling |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0006626 | protein targeting to mitochondrion |
| Biological Process | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0043067 | regulation of programmed cell death |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0090128 | regulation of synapse maturation |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.