Search Results

Overview

Uniprot ID	P63135
Protein Name	Endogenous retrovirus group K member 7 Pol protein
Gene Name	ERVK-7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
231	GLAIASDKIQTSTPF

Function

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution

Protein Sequence

10 NKSRKRRNRL 20 SFLGAATVEP 30 PKPIPLTWKT 40 EKPVWVNQWP 50 LPKQKLEALH 60 LLANEQLEKG 70 HIEPSFSPWN 80 SPVFVIQKKS 90 GKWRMLTDLR 100 AVNAVIQPMG 110 PLQPGLPSPA 120 MIPKDWPLII 130 IDLKDCFFTI 140 PLAEQDCEKF 150 AFTIPAINNK 160 EPATRFQWKV 170 LPQGMLNSPT 180 ICQTFVGRAL 190 QPVREKFSDC 200 YIIHYIDDIL 210 CAAETRDKLI 220 DCYTFLQAEV 230 ANAGLAIASD 240 KIQTSTPFHY 250 LGMQIENRKI 260 KQQKIEIRKD 270 TLKTLNDFQK 280 LLGDINWIRP 290 TLGIPTYAMS 300 NLFSILRGDS 310 DLNSKRILTP 320 EATKEIKLVE 330 EKIQSAQINR 340 IDPLAPLQLL 350 IFATAHSPTG 360 IIIQNTDLVE 370 WSFLPHSTVK 380 TFTLYLDQIA 390 TLIGQTRLRI 400 IKLCGNDPDK 410 IVVPLTKEQV 420 RQAFINSGAW 430 QIGLANFVGI 440 IDNHYPKTKI 450 FQFLKLTTWI 460 LPKITRREPL 470 ENALTVFTDG 480 SSNGKAAYTG 490 PKERVIKTPY 500 QSAQRAELVA 510 VITVLQDFDQ 520 PINIISDSAY 530 VVQATRDVET 540 ALIKYSMDDQ 550 LNQLFNLLQQ 560 TVRKRNFPFY 570 ITHIRAHTNL 580 PGPLTKANEQ 590 ADLLVSSALI 600 KAQELHALTH 610 VNAAGLKNKF 620 DVTWKQAKDI 630 VQHCTQCQIL 640 HLPTQEAGVN 650 PRGLCPNALW 660 QMDVTHVPSF 670 GRLSYVHVTV 680 DTYSHFIWAT 690 CQTGESTSHV 700 KKHLLSCFAV 710 MGVPEKIKTD 720 NGPGYCSKAF 730 QKFLSQWKIS 740 HTTGIPYNSQ 750 GQAIVERTNR 760 TLKTQLVKQK 770 EGGDSKECTT 780 PQMQLNLALY 790 TLNFLNIYRN 800 QTTTSAEQHL 810 TGKKNSPHEG 820 KLIWWKDNKN 830 KTWEIGKVIT 840 WGRGFACVSP 850 GENQLPVWIP 860 TRHLKFYNEP 870 IGDAKKRAST 880 EMVTPVTWMD 890 NPIEIYVNDS 900 VWVPGPIDDR 910 CPAKPEEEGM 920 MINISIGYRY 930 PPICLGRAPG 940 CLMPAVQNWL 950 VEVPTVSPIS 960 RFTYHMVSGM 970 SLRPRVNYLQ 980 DFSYQRSLKF 990 RPKGKPCPKE 1000 IPKESKNTEV 1010 LVWEECVANS 1020 AVILQNNEFG 1030 TIIDWAPRGQ 1040 FYHNCSGQTQ 1050 SCPSAQVSPA 1060 VDSDLTESLD 1070 KHKHKKLQSF 1080 YPWEWGEKGI 1090 STPRPKIVSP 1100 VSGPEHPELW 1110 RLTVASHHIR 1120 IWSGNQTLET 1130 RDCKPFYTID 1140 LNSSLTVPLQ 1150 SCVKPPYMLV 1160 VGNIVIKPDS 1170 QTITCENCRL 1180 LTCIDSTFNW 1190 QHRILLVRAR 1200 EGVWIPVSMD 1210 RPWEASPSVH 1220 ILTEVLKGVL 1230 NRSKRFIFTL 1240 IAVIMGLIAV 1250 TATAAVAGVA 1260 LHSSVQSVNF 1270 VNDWQKNSTR 1280 LWNSQSSIDQ 1290 KLANQINDLR 1300 QTVIWMGDRL 1310 MSLEHRFQLQ 1320 CDWNTSDFCI 1330 TPQIYNESEH 1340 HWDMVRRHLQ 1350 GREDNLTLDI 1360 SKLKEQIFEA 1370 SKAHLNLVPG 1380 TEAIAGVADG 1390 LANLNPVTWV 1400 KTIGSTTIIN 1410 LILILVCLFC 1420 LLLVCRCTQQ 1430 LRRDSDHRER 1440 AMMTMAVLSK 1450 RKGGNVGKSK RDQIVTVSV

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0035613	RNA stem-loop binding
Molecular Function	GO:0003964	RNA-directed DNA polymerase activity
Molecular Function	GO:0004523	RNA-DNA hybrid ribonuclease activity
Molecular Function	GO:0005198	structural molecule activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0015074	DNA integration
Biological Process	GO:0006310	DNA recombination
Biological Process	GO:0006261	DNA-templated DNA replication

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.