Search Results
Overview
| Uniprot ID | P63167 |
|---|---|
| Protein Name | Dynein light chain 1, cytoplasmic |
| Gene Name | DYNLL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | LEKYNIEKDIAAHIK |
| 43 | KDIAAHIKKEFDKKY |
| 44 | DIAAHIKKEFDKKYN |
| 49 | IKKEFDKKYNPTWHC |
| 9 | CDRKAVIKNADMSEE |
Function
Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (PubMed:10198631, PubMed:15193260, PubMed:15891768, PubMed:16684779, PubMed:30464262, PubMed:37696958). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (PubMed:30464262, PubMed:37696958). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (PubMed:37696958). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (PubMed:15891768, PubMed:16684779). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (PubMed:10198631, PubMed:15193260). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (PubMed:10198631, PubMed:15193260)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0097542 | ciliary tip |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005868 | cytoplasmic dynein complex |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0101003 | ficolin-1-rich granule membrane |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0001673 | male germ cell nucleus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Molecular Function | GO:0045505 | dynein intermediate chain binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036487 | nitric-oxide synthase inhibitor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035721 | intraciliary retrograde transport |
| Biological Process | GO:0044458 | motile cilium assembly |
| Biological Process | GO:0110027 | negative regulation of DNA strand resection involved in replication fork processing |
| Biological Process | GO:0042326 | negative regulation of phosphorylation |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:0032388 | positive regulation of intracellular transport |
| Biological Process | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| Biological Process | GO:0007286 | spermatid development |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
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[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.