Search Results
Overview
| Uniprot ID | P63170 |
|---|---|
| Protein Name | Dynein light chain 1, cytoplasmic |
| Gene Name | Dynll1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | LEKYNIEKDIAAHIK |
| 43 | KDIAAHIKKEFDKKY |
| 49 | IKKEFDKKYNPTWHC |
| 9 | CDRKAVIKNADMSEE |
Function
Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11746667, PubMed:8702622). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11746667, PubMed:8702622). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (PubMed:11746667, PubMed:8702622). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (By similarity). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (By similarity). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (PubMed:8864115). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (By similarity). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0045505 | dynein intermediate chain binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036487 | nitric-oxide synthase inhibitor activity |
| Molecular Function | GO:0030235 | nitric-oxide synthase regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0035721 | intraciliary retrograde transport |
| Biological Process | GO:0160040 | mitocytosis |
| Biological Process | GO:0044458 | motile cilium assembly |
| Biological Process | GO:0110027 | negative regulation of DNA strand resection involved in replication fork processing |
| Biological Process | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0042326 | negative regulation of phosphorylation |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:1902857 | positive regulation of non-motile cilium assembly |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0007286 | spermatid development |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0008180 | COP9 signalosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005868 | cytoplasmic dynein complex |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030286 | dynein complex |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005739 | mitochondrion |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.