Search Results
Overview
| Uniprot ID | P63215 |
|---|---|
| Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 |
| Gene Name | GNG3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | MSIGQARKMVEQLKI |
| 36 | LCRIKVSKAAADLMT |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Protein Sequence
10
MKGETPVNST
20
MSIGQARKMV
30
EQLKIEASLC
40
RIKVSKAAAD
50
LMTYCDAHAC
60
EDPLITPVPT
70
SENPFREKKF
FCALL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005834 | heterotrimeric G-protein complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0031681 | G-protein beta-subunit binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.