Search Results
Overview
| Uniprot ID | P63244 |
|---|---|
| Protein Name | Small ribosomal subunit protein RACK1 |
| Gene Name | RACK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | IVSCGWDKLVKVWNL |
| 175 | CGWDKLVKVWNLANC |
| 183 | VWNLANCKLKTNHIG |
| 212 | SLCASGGKDGQAMLW |
| 38 | ILSASRDKTIIMWKL |
Function
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:1903751 | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:1990630 | IRE1-RACK1-PP2A complex |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0015935 | small ribosomal subunit |
| Molecular Function | GO:0051434 | BH3 domain binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0030332 | cyclin binding |
| Molecular Function | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008200 | ion channel inhibitor activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0042169 | SH2 domain binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0045182 | translation regulator activity |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071363 | cellular response to growth factor stimulus |
| Biological Process | GO:0002181 | cytoplasmic translation |
| Biological Process | GO:0007369 | gastrulation |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:1900102 | negative regulation of endoplasmic reticulum unfolded protein response |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0050765 | negative regulation of phagocytosis |
| Biological Process | GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0032091 | negative regulation of protein binding |
| Biological Process | GO:0045879 | negative regulation of smoothened signaling pathway |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:2001125 | negative regulation of translational frameshifting |
| Biological Process | GO:0030178 | negative regulation of Wnt signaling pathway |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:2000543 | positive regulation of gastrulation |
| Biological Process | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0051901 | positive regulation of mitochondrial depolarization |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0106070 | regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0051302 | regulation of cell division |
| Biological Process | GO:2000114 | regulation of establishment of cell polarity |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0072344 | rescue of stalled cytosolic ribosome |
| Biological Process | GO:0048511 | rhythmic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.