Search Results
Overview
| Uniprot ID | P63259 |
|---|---|
| Protein Name | Actin, cytoplasmic 2 |
| Gene Name | Actg1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | TEAPLNPKANREKMT |
| 191 | DLTDYLMKILTERGY |
| 215 | IVRDIKEKLCYVALD |
| 315 | GIADRMQKEITALAP |
| 326 | ALAPSTMKIKIIAPP |
| 328 | APSTMKIKIIAPPER |
| 50 | VMVGMGQKDSYVGDE |
| 61 | VGDEAQSKRGILTLK |
Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity)
Protein Sequence
10
MEEEIAALVI
20
DNGSGMCKAG
30
FAGDDAPRAV
40
FPSIVGRPRH
50
QGVMVGMGQK
60
DSYVGDEAQS
70
KRGILTLKYP
80
IEHGIVTNWD
90
DMEKIWHHTF
100
YNELRVAPEE
110
HPVLLTEAPL
120
NPKANREKMT
130
QIMFETFNTP
140
AMYVAIQAVL
150
SLYASGRTTG
160
IVMDSGDGVT
170
HTVPIYEGYA
180
LPHAILRLDL
190
AGRDLTDYLM
200
KILTERGYSF
210
TTTAEREIVR
220
DIKEKLCYVA
230
LDFEQEMATA
240
ASSSSLEKSY
250
ELPDGQVITI
260
GNERFRCPEA
270
LFQPSFLGME
280
SCGIHETTFN
290
SIMKCDVDIR
300
KDLYANTVLS
310
GGTTMYPGIA
320
DRMQKEITAL
330
APSTMKIKII
340
APPERKYSVW
350
IGGSILASLS
360
TFQQMWISKQ
370
EYDESGPSIV
HRKCF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Biological Process | GO:0051492 | regulation of stress fiber assembly |
| Biological Process | GO:1900242 | regulation of synaptic vesicle endocytosis |
| Biological Process | GO:0150111 | regulation of transepithelial transport |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0009612 | response to mechanical stimulus |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0120192 | tight junction assembly |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0120220 | basal body patch |
| Cellular Component | GO:0044305 | calyx of Held |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0097433 | dense body |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0035267 | NuA4 histone acetyltransferase complex |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098871 | postsynaptic actin cytoskeleton |
| Cellular Component | GO:0099143 | presynaptic actin cytoskeleton |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005522 | profilin binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0098973 | structural constituent of postsynaptic actin cytoskeleton |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0001738 | morphogenesis of a polarized epithelium |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:1902396 | protein localization to bicellular tight junction |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.