Search Results

Overview

Uniprot IDP63261
Protein NameActin, cytoplasmic 2
Gene NameACTG1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
113 TEAPLNPKANREKMT
191 DLTDYLMKILTERGY
213 REIVRDIKEKLCYVA
215 IVRDIKEKLCYVALD
291 KCDVDIRKDLYANTV
315 GIADRMQKEITALAP
326 ALAPSTMKIKIIAPP
328 APSTMKIKIIAPPER
336 IIAPPERKYSVWIGG
50 VMVGMGQKDSYVGDE
61 VGDEAQSKRGILTLK
68 KRGILTLKYPIEHGI

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity)

Protein Sequence

10 MEEEIAALVI 20 DNGSGMCKAG 30 FAGDDAPRAV 40 FPSIVGRPRH 50 QGVMVGMGQK 60 DSYVGDEAQS 70 KRGILTLKYP 80 IEHGIVTNWD 90 DMEKIWHHTF 100 YNELRVAPEE 110 HPVLLTEAPL 120 NPKANREKMT 130 QIMFETFNTP 140 AMYVAIQAVL 150 SLYASGRTTG 160 IVMDSGDGVT 170 HTVPIYEGYA 180 LPHAILRLDL 190 AGRDLTDYLM 200 KILTERGYSF 210 TTTAEREIVR 220 DIKEKLCYVA 230 LDFEQEMATA 240 ASSSSLEKSY 250 ELPDGQVITI 260 GNERFRCPEA 270 LFQPSFLGME 280 SCGIHETTFN 290 SIMKCDVDIR 300 KDLYANTVLS 310 GGTTMYPGIA 320 DRMQKEITAL 330 APSTMKIKII 340 APPERKYSVW 350 IGGSILASLS 360 TFQQMWISKQ 370 EYDESGPSIV HRKCF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Biological Process GO:0001738 morphogenesis of a polarized epithelium
Biological Process GO:0070527 platelet aggregation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0090303 positive regulation of wound healing
Biological Process GO:1902396 protein localization to bicellular tight junction
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0051492 regulation of stress fiber assembly
Biological Process GO:1900242 regulation of synaptic vesicle endocytosis
Biological Process GO:0150111 regulation of transepithelial transport
Biological Process GO:0120192 tight junction assembly
Cellular Component GO:0005884 actin filament
Cellular Component GO:0043296 apical junction complex
Cellular Component GO:0030424 axon
Cellular Component GO:0120220 basal body patch
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0044305 calyx of Held
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0097433 dense body
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Cellular Component GO:0030016 myofibril
Cellular Component GO:0035267 NuA4 histone acetyltransferase complex
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0045202 synapse
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0098973 structural constituent of postsynaptic actin cytoskeleton
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007409 axonogenesis
Biological Process GO:0048870 cell motility
Biological Process GO:0035633 maintenance of blood-brain barrier

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.