Search Results
Overview
| Uniprot ID | P63279 |
|---|---|
| Protein Name | SUMO-conjugating enzyme UBC9 |
| Gene Name | UBE2I |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | QNRVEYEKRVRAQAK |
| 18 | QERKAWRKDHPFGFV |
Function
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). Sumoylates SHMT1 at 'Lys-38' or 'Lys-39' leading to RAN-dependent nuclear import of SHMT1 (PubMed:17446168). Also sumoylates TYMS and DHFR (PubMed:18067453)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0106068 | SUMO ligase complex |
| Cellular Component | GO:0000795 | synaptonemal complex |
| Cellular Component | GO:1990234 | transferase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043398 | HLH domain binding |
| Molecular Function | GO:0071535 | RING-like zinc finger domain binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0044388 | small protein activating enzyme binding |
| Molecular Function | GO:0061656 | SUMO conjugating enzyme activity |
| Molecular Function | GO:0019789 | SUMO transferase activity |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Molecular Function | GO:0008134 | transcription factor binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0051170 | import into nucleus |
| Biological Process | GO:0007084 | mitotic nuclear membrane reassembly |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051168 | nuclear export |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.