Search Results
Overview
| Uniprot ID | P63329 |
|---|---|
| Protein Name | Protein phosphatase 3 catalytic subunit alpha |
| Gene Name | Ppp3ca |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | EPKAIDPKLSTTDRV |
| 32 | PSHRLTAKEVFDNDG |
| 466 | KGFSPQHKITSFEEA |
| 47 | KPRVDILKAHLMKEG |
| 474 | ITSFEEAKGLDRINE |
| 52 | ILKAHLMKEGRLEES |
Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:1322410, PubMed:24018048). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (PubMed:23699505). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (By similarity). Negatively regulates SLC9A1 activity (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005955 | calcineurin complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0036057 | slit diaphragm |
| Cellular Component | GO:0045202 | synapse |
| Biological Process | GO:1905205 | positive regulation of connective tissue replacement |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0090193 | positive regulation of glomerulus development |
| Biological Process | GO:0045669 | positive regulation of osteoblast differentiation |
| Biological Process | GO:0045672 | positive regulation of osteoclast differentiation |
| Biological Process | GO:0046878 | positive regulation of saliva secretion |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0061006 | regulation of cell proliferation involved in kidney morphogenesis |
| Biological Process | GO:0097205 | renal filtration |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0048741 | skeletal muscle fiber development |
| Biological Process | GO:0014883 | transition between fast and slow fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0097720 | calcineurin-mediated signaling |
| Biological Process | GO:0033173 | calcineurin-NFAT signaling cascade |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0014898 | cardiac muscle hypertrophy in response to stress |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0016311 | dephosphorylation |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0033555 | multicellular organismal response to stress |
| Biological Process | GO:0110062 | negative regulation of angiotensin-activated signaling pathway |
| Biological Process | GO:0045955 | negative regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:0050774 | negative regulation of dendrite morphogenesis |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0046676 | negative regulation of insulin secretion |
| Biological Process | GO:0023057 | negative regulation of signaling |
| Biological Process | GO:0070262 | peptidyl-serine dephosphorylation |
| Biological Process | GO:0042104 | positive regulation of activated T cell proliferation |
| Biological Process | GO:1903235 | positive regulation of calcium ion-dependent exocytosis of neurotransmitter |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:1903244 | positive regulation of cardiac muscle hypertrophy in response to stress |
| Biological Process | GO:0045785 | positive regulation of cell adhesion |
| Biological Process | GO:0030335 | positive regulation of cell migration |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.