Search Results
Overview
| Uniprot ID | P67778 |
|---|---|
| Protein Name | Prohibitin 1 |
| Gene Name | Phb1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | RARFVVEKAEQQKKA |
| 208 | EKAEQQKKAAIISAE |
| 4 | ****MAAKVFESIGK |
Function
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:23241883, PubMed:24856930, PubMed:29324904). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (PubMed:24947361). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity)
Protein Sequence
10
MAAKVFESIG
20
KFGLALAVAG
30
GVVNSALYNV
40
DAGHRAVIFD
50
RFRGVQDIVV
60
GEGTHFLIPW
70
VQKPIIFDCR
80
SRPRNVPVIT
90
GSKDLQNVNI
100
TLRILFRPVA
110
SQLPRIYTSI
120
GEDYDERVLP
130
SITTEILKSV
140
VARFDAGELI
150
TQRELVSRQV
160
SDDLTERAAT
170
FGLILDDVSL
180
THLTFGKEFT
190
EAVEAKQVAQ
200
QEAERARFVV
210
EKAEQQKKAA
220
IISAEGDSKA
230
AELIANSLAT
240
AGDGLIELRK
250
LEAAEDIAYQ
260
LSRSRNITYL
270
PAGQSVLLQL
PQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0035632 | mitochondrial prohibitin complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0001850 | complement component C3a binding |
| Molecular Function | GO:0001851 | complement component C3b binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0031871 | proteinase activated receptor binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0042113 | B cell activation |
| Biological Process | GO:0071354 | cellular response to interleukin-6 |
| Biological Process | GO:0071897 | DNA biosynthetic process |
| Biological Process | GO:0040029 | epigenetic regulation of gene expression |
| Biological Process | GO:0044830 | host-mediated perturbation of viral RNA genome replication |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:2000323 | negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway |
| Biological Process | GO:0042177 | negative regulation of protein catabolic process |
| Biological Process | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001552 | ovarian follicle atresia |
| Biological Process | GO:0001541 | ovarian follicle development |
| Biological Process | GO:0045917 | positive regulation of complement activation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0002639 | positive regulation of immunoglobulin production |
| Biological Process | GO:0032740 | positive regulation of interleukin-17 production |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:0050847 | progesterone receptor signaling pathway |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0035902 | response to immobilization stress |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0039529 | RIG-I signaling pathway |
| Biological Process | GO:0046718 | symbiont entry into host cell |
| Biological Process | GO:0072538 | T-helper 17 type immune response |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0098891 | extrinsic component of presynaptic active zone membrane |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.