Search Results
Overview
| Uniprot ID | P68032 |
|---|---|
| Protein Name | Actin, alpha cardiac muscle 1 |
| Gene Name | ACTC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | TEAPLNPKANREKMT |
| 293 | KCDIDIRKDLYANNV |
| 317 | GIADRMQKEITALAP |
| 328 | ALAPSTMKIKIIAPP |
| 330 | APSTMKIKIIAPPER |
| 361 | FQQMWISKQEYDEAG |
| 52 | VMVGMGQKDSYVGDE |
| 63 | VGDEAQSKRGILTLK |
| 70 | KRGILTLKYPIEHGI |
| 86 | TNWDDMEKIWHHTFY |
Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells
Protein Sequence
10
MCDDEETTAL
20
VCDNGSGLVK
30
AGFAGDDAPR
40
AVFPSIVGRP
50
RHQGVMVGMG
60
QKDSYVGDEA
70
QSKRGILTLK
80
YPIEHGIITN
90
WDDMEKIWHH
100
TFYNELRVAP
110
EEHPTLLTEA
120
PLNPKANREK
130
MTQIMFETFN
140
VPAMYVAIQA
150
VLSLYASGRT
160
TGIVLDSGDG
170
VTHNVPIYEG
180
YALPHAIMRL
190
DLAGRDLTDY
200
LMKILTERGY
210
SFVTTAEREI
220
VRDIKEKLCY
230
VALDFENEMA
240
TAASSSSLEK
250
SYELPDGQVI
260
TIGNERFRCP
270
ETLFQPSFIG
280
MESAGIHETT
290
YNSIMKCDID
300
IRKDLYANNV
310
LSGGTTMYPG
320
IADRMQKEIT
330
ALAPSTMKIK
340
IIAPPERKYS
350
VWIGGSILAS
360
LSTFQQMWIS
370
KQEYDEAGPS
IVHRKCF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0030017 | sarcomere |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0000146 | microfilament motor activity |
| Molecular Function | GO:0017022 | myosin binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030048 | actin filament-based movement |
| Biological Process | GO:0033275 | actin-myosin filament sliding |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0055008 | cardiac muscle tissue morphogenesis |
| Biological Process | GO:0055003 | cardiac myofibril assembly |
| Biological Process | GO:0060047 | heart contraction |
| Biological Process | GO:0090131 | mesenchyme migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0030240 | skeletal muscle thin filament assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.