Overview
| Uniprot ID | P68037 |
|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 L3 |
|---|
| Gene Name | Ube2l3 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 138 |
KDRKKFCKNAEEFTK |
Function
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex (By similarity). In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis
Protein Sequence
10
MAASRRLMKE
20
LEEIRKCGMK
30
NFRNIQVDEA
40
NLLTWQGLIV
50
PDNPPYDKGA
60
FRIEINFPAE
70
YPFKPPKITF
80
KTKIYHPNID
90
EKGQVCLPVI
100
SAENWKPATK
110
TDQVIQSLIA
120
LVNDPQPEHP
130
LRADLAEEYS
140
KDRKKFCKNA
150
EEFTKKYGEK
RPVD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098793 |
presynapse |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0061631 |
ubiquitin conjugating enzyme activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Molecular Function |
GO:0097027 |
ubiquitin-protein transferase activator activity |
| Molecular Function |
GO:0004842 |
ubiquitin-protein transferase activity |
| Biological Process |
GO:0044770 |
cell cycle phase transition |
| Biological Process |
GO:0008283 |
cell population proliferation |
| Biological Process |
GO:0071385 |
cellular response to glucocorticoid stimulus |
| Biological Process |
GO:0071383 |
cellular response to steroid hormone stimulus |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0031398 |
positive regulation of protein ubiquitination |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.