Overview
| Uniprot ID | P68182 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | Prkacb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
KEFLAKAKEDFLRKW |
| 280 |
LLQVDLTKRFGNLKN |
| 84 |
KQKVVKLKQIEHTLN |
| 93 |
IEHTLNEKRILQAVE |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MGNTAIAKKG
20
SEVESVKEFL
30
AKAKEDFLRK
40
WENPPPSNAG
50
LEDFERKKTL
60
GTGSFGRVML
70
VKHKATEQYY
80
AMKILDKQKV
90
VKLKQIEHTL
100
NEKRILQAVE
110
FPFLVRLEYS
120
FKDNSNLYMV
130
MEYVPGGEMF
140
SHLRRIGRFS
150
EPHARFYAAQ
160
IVLTFEYLHS
170
LDLIYRDLKP
180
ENLLIDHQGY
190
IQVTDFGFAK
200
RVKGRTWTLC
210
GTPEYLAPEI
220
ILSKGYNKAV
230
DWWALGVLIY
240
EMAAGYPPFF
250
ADQPIQIYEK
260
IVSGKVRFPS
270
HFSSDLKDLL
280
RNLLQVDLTK
290
RFGNLKNGVS
300
DIKTHKWFAT
310
TDWIAIYQRK
320
VEAPFIPKFR
330
GSGDTSNFDD
340
YEEEEIRVSI
350
TEKCGKEFCE
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005952 |
cAMP-dependent protein kinase complex |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0097546 |
ciliary base |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0019870 |
potassium channel inhibitor activity |
| Molecular Function |
GO:0034237 |
protein kinase A regulatory subunit binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Biological Process |
GO:0007189 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0051447 |
negative regulation of meiotic cell cycle |
| Biological Process |
GO:0045879 |
negative regulation of smoothened signaling pathway |
| Biological Process |
GO:1904262 |
negative regulation of TORC1 signaling |
| Biological Process |
GO:0001843 |
neural tube closure |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0070613 |
regulation of protein processing |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.