Search Results
Overview
| Uniprot ID | P68211 |
|---|---|
| Protein Name | Alpha-endosulfine |
| Gene Name | ENSA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | PQDLPQRKSSLVTSK |
| 114 | KSSLVTSKLAGGQVE |
| 36 | PEKAEEAKLKAKYPS |
| 40 | EEAKLKAKYPSLGQK |
| 80 | AKAKMKNKQLPSAGP |
Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)
Protein Sequence
10
MSQKQEEENP
20
AEETGEEKQD
30
TQEKEGILPE
40
KAEEAKLKAK
50
YPSLGQKPGG
60
SDFLMKRLQK
70
GQKYFDSGDY
80
NMAKAKMKNK
90
QLPSAGPDKN
100
LVTGDHIPTP
110
QDLPQRKSSL
120
VTSKLAGGQV
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0019212 | phosphatase inhibitor activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0000278 | mitotic cell cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.